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Biomedical engineering is the key technology of the 21st century. The possibility to exploit the structures and process of advanced materials for novel functional materials, biosensors, stem cells technology, regenerative medicine, drug delivery systems has created the rapidly growing field of biomaterials technology. Designed as a broad survey of the field, this book combines contributions from molecular biology, materials science and medicine to fathom the full scope of current and future developments.

　　It is divided into four main sections:

　　•Interface systems
　　•Physiochemical properties
　　•Structures of biomaterials
　　•Medical applications

　　Each chapter describes in detail currently valuable methods and contains numerous references to the primary literature, making this the perfect “filed guide” for chemists, biologists and physicians who want to explore the fascinating world of biomedical engineering.

作者簡介

Hossein Hosseinkhani

　　Professor Hossein Hosseinkhani received his Ph.D degree in Polymer Chemistry in the field of Biomedical Engineering from Kyoto University, Japan (1998-2002). Dr. Hosseinkahni has broad experience in life sciences and is expert in nanotechnology, biomaterials and stem cells technology for regenerative medicine and biomedical engineering applications. He has been awarded several prestigious fellowships including JSPS Fellowship of Japan   at Institute for Frontier Medical Sciences, Kyoto University Hospital (2002–2004), ICYS Research Fellow of Japan at Notational Institute for Materials Science (2004–2008), IRIIMS Research Fellow of Japan at International Research Institute for Integrated Medical Sciences, Tokyo Women’s Medical University (2008–2009), and Visiting Scientist at Center for Biomedical Engineering, Massachusetts Institute of Technology (MIT), USA (2007–2009). Dr. Hosseinkhani has 50 issued Japan and U.S. patents, several U.S. patents pending and has authored over 100 international publications in prestigious international journals and over 200 presentations at international conferences till present time. Currently, he is Director of Bioengineering Program and Professor at the Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology (Taiwan Tech).

Keng-Liang Ou

　　Professor Keng-Liang Ou graduated from Mechanical Engineering Ph.D. program at National Chiao Tung University, Taiwan. Professor Ou came to Taipei Medical University to pursuit on biomaterial research and development and he becomes the current elected Dean of College of Oral Medicine in Taipei Medical University, Taiwan. He is also in charge of Graduate Institute of Biomedical Materials and Tissue Engineering, Research Center for Biomedical Implants and Microsurgery Devices and Research Center for Biomedical Devices and Prototyping Production. Besides the institutional positions, he is the President of Institute of Plasma Engineering Taiwan, the leader of The Taiwan society for metal heat treatment and the Head Taiwan Oral Biomedical Engineering Association. Professor Ou focuses his researches on, Biomaterials, Bioengineering, Nanotechnology, and Biomedical Devices. He is the leader and organizer for the biomedical product design, production, manufacturing, testing, legalization and market planning, with supports from team of scientists and researchers with different expertise. Professor Ou was honorably awarded with the 49th Ten Outstanding Young Persons of Taiwan on 2011.

Chapter 1 Introduction to Biomaterials

Chapter 2 Biomedical Materialxs
2.1 Introduction
2.2 Biodegradable Polymers
2.3 Natural Biomaterials
2.4 Biodegradable Nanoparticles
2.5 Controlled Release Drug Delivery Systems
using Biomaterials
References

Chapter 3 Physical Properties of Biomaterials
3.1 Physical properties of materials
3.2 Introduction of spectroscopy
3.3 Thermal properties
3.4 Thermal analysis
Reference

Chapter 4 Mechanical Behavior of Biomaterials
4.1 Introduction
4.2 Mechanics of Materials
4.3 Mechanical Testing
4.4 Fracture of Materials
References

Chapter 5 Hydrogels in Medicine
5.1 Introduction
5.2 Mechanical properties of hydrogels and
interpenetrating networks
5.3 Engineering hydrogels with controlled
mechanical , chemical and biological
properties
5.4 Developing methods of fabricating composite
biodegradable hydrogels using IPNs
5.5 Engineering approaches to deliver growth
factors from hydrogels
5.6 Drug delivery systems using polymeric
hydrogel
References

Chapter 6 Surface treatment of biomedical materials
6.1 Chemical method
6.2 Electrochemical method
6.3 Plasma method
6.4 Ion beam implantation
6.5 Characterization technique
Reference

Chapter 7 3D In Vitro Systems for Biological Application
7.1 Introduction
7.2 3D In Vitro Systems
7.3 3 D Cellular Microenvironment
7.4 3D Technology on Frontier of Neuroscience
7.5 Regenerative medicine therapy
7.6 Future prospects
References

Chapter 8 Cell and Gene Therapy based on Biomaterials
Technology
8.1 Introduction
8.2 Engineering Cellular Environment
8.3 Combinatorial Cell/Polymer Interaction
Studies
8.4 Biomaterial Control of Mesenchymal Stem
Cell Differentiation
8.5 Biomaterial Control of Embryonic Stem Cell
Differentiation
8.6 Classification of cellular barriers systems
8.7 Calissification of gene delivery systems
References

Chapter 9 Nanotechnology inMedicine
9.1 Introduction
9.2 Classification of nanomaterials
9.3 Nanocarriers
9.4 Nanoscaffoling Materials
9.5 Biocompatibility and toxicity of nanomaterials
9.6 Safety issue of nanomaterials
9.7 Limitations of nanomaterials technology in
nature and medicine
9.8 Future Prospects
References

Biomaterials technology is one newly emerging biomedical form to create new device and induce the regeneration of detective and injured body tissues and organs as well as to substitute the biological functions of damaged organs. To this end, the cells of high proliferation and differentiation potentials are used with being combined with some cell scaffolds and the biological signals of growth factor and gene. Since there are some cases in which cells are genetically innovated to produce the growth factors inducible angiogenesis and tissue regeneration, the technology of gene delivery is also necessary for tissue engineering. Current developments in the technological fields of biomedical and tissue engineering, bioengineering, biomechanics, microfabrication and microfluidics have lead to highly complex and pertinent new tools for in vitro and in vivo applications. The purpose of biomaterials technology is to mimic organ tissues in vitro in order to partially reduce the amount of in vivo testing. These types of systems can enhance functionality of cells by mimicking the tissue architecture complexities when compared to in vitro analysis but at the same time present a more rapid and simple process when compared to in vivo testing procedures. The development of new technology for analysis of engineered tissues can be achieved through the combination of these research domains. Combining these advanced research domains, we then present new area of technology that allows analysis in vitro on engineered tissues. An extension of the biomaterials technology has also allowed tissue and organs development, which can be considered as a first step towards the replacement of animal testing using a combined organ model.

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