Hydrogen Immunotherapy Makes Cancer Disappear

Hydrogen Immunotherapy Makes Cancer Disappear pdf epub mobi txt 电子书 下载 2025

赤木純兒(Junji Akagi)
图书标签:
  • 氢气疗法
  • 癌症免疫疗法
  • 肿瘤治疗
  • 氢分子
  • 医学研究
  • 替代疗法
  • 健康
  • 癌症预防
  • 抗氧化
  • 氢疗法
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具体描述

  Advice from a Japanese Authority on Immuno-Oncology about how to Enhance Your Immunity Swiftly and Build a Robust Body

  Immune Deficiency, Antineoplastic Drugs, and Radiotherapy Are Unfavorable for Cancer Treatment

  The First Ever Exposition of “Hydrogen Immunotherapy”

  .The Globally First Attempt to Fight Cancer by the Application of Hydrogen, with over 400 Evidence-Based Cases Included
  .Significant Prolongation of the Life Expectancy of Many End-Stage and Recurrent Cancer Patients

  Hydrogen Activates Human Immune Cells!

  The probability of developing cancer has increased significantly with the extension of the average human lifespan. There is an increasing number of literature demonstrating the diverse bioactivities inducible by oxyhydrogen inhalation, including anti-inflammatory, anti-reactive oxygen species (ROS), and antineoplastic effects.

  Evidence has also suggested that hydrogen may be used to mitigate the side effects of traditional chemotherapy, or to inhibit the growth of cancer cells and xenotransplanted tumor. In addition, the application of oxyhydrogen in the treatment of COVID-19 may not only reduce the symptom associated with difficulty breathing, but also exhibit the critical anti-inflammatory effect.

  This book is the first collection of the research and comments made by a Japanese immuno-oncologist on “hydrogen immunotherapy.” Apart from the promising and extensive application in clinical treatment, hydrogen is helpful to prolong the healthy lifespan when used in daily care and health maintenance as well.

  Recommended by
  Dr. He-Chang Kuo, M.D.│professor of the School of Medicine of Chang Gung University
  Dr. Ming-Hsien Huang, M.D.│vice superintendent of E-Da Cancer Hospital
  Dr. Wen-Chang Lin, Ph.D.│chairman of Epoch Energy Technology Co. and Ota Hydrogen Biotech

名人推薦

  “Certainly, research is the foundation of medical advancement. Dr. Akagi has been contributing to the progression of hydrogen medicine through his clinical trials and publications in international journals. Now, he has even written a popular science book to share the collection and analysis of these clinical cases, which is a demonstration of a true spirit of generous giving.”—Dr. He-Chang Kuo│Professor of the School of Medicine of Chang Gung University

  “From the perspective of cancer treatment, Dr. Akagi has presented an abundance of empirical data associated with oxyhydrogen therapy to offer a new treatment position to the world.”—Dr. Ming-Hsien Huang│Vice Superintendent of E-Da Cancer Hospital

  “Hydrogen Immunotherapy makes cancer disappear is one of the bestsellers in Japan. The complete case data and the treatment scheme studied and recorded by Dr. Akagi are surely great contribution to oxyhydrogen applications in the future of medicine. This is a book definitely worth recommending.” —Dr. Wen-Chang Lin, Ph.D.│chairman of Epoch Energy Technology Co. and Ota Hydrogen Biotech
好的,这是一本关于生命科学和新兴疗法的书籍简介,完全基于您提供书名中未包含的信息进行创作,力求详尽且自然。 --- 探索生命前沿:细胞重编程与精准医疗的未来图景 本书聚焦于当前生物医学领域最引人注目、最具颠覆性的两大方向:基于基因编辑的细胞重编程技术,以及下一代靶向药物输送系统如何重新定义癌症治疗的疆界。本书并非对特定疗法的详尽临床指南,而是一部面向关注科技前沿的专业人士及深度爱好者的深度洞察报告,旨在勾勒出未来十年内,人类如何利用自身对生命编码的理解,来重塑疾病治疗范式的宏伟蓝图。 第一部分:解码生命蓝图——重编程技术的革命 本书的开篇深入探讨了体细胞重编程技术的理论基石及其在生物医学工程中的实际应用。我们不再仅仅满足于体外培养,而是致力于在活体生物体内实现细胞命运的精确调控。 1. 诱导多能干细胞(iPSCs)的进阶应用与伦理考量: 我们详述了从山中因子(Yamanaka Factors)到新型、更高效、更安全的“非病毒载体”重编程方法的演进。重点分析了如何克服当前iPSC技术在临床转化中的两大核心障碍:插入性突变的风险和免疫原性问题。书中详细介绍了“直接重编程”技术(Direct Reprogramming),即不通过多能干细胞阶段,直接将一种成熟细胞(如皮肤成纤维细胞)转化为另一种所需细胞类型(如神经元或心肌细胞)的最新进展。这为再生医学提供了前所未有的直接通路。 2. 表观遗传调控与基因沉默: 细胞身份的锁定机制,即表观遗传学,是本书深入探讨的另一个核心领域。我们详细剖析了DNA甲基化、组蛋白修饰等分子层面的开关如何决定细胞的“性格”。书籍引入了新兴的“表观遗传编辑”工具,例如基于CRISPR-Cas9或dCas9的激活子(CRISPRa)和抑制子(CRISPRi)系统,这些系统能够精确调控基因的表达水平,而无需永久性地改变DNA序列本身。这种“软性”干预被视为解决复杂、多基因疾病的理想路径,尤其在神经退行性疾病的研究中展现出巨大潜力。 3. 细胞工程学的“工厂化”生产: 本书的这一章节侧重于将实验室成果转化为可大规模、标准化生产的生物制品。我们探讨了生物反应器设计、自动化过程控制,以及如何建立符合cGMP(现行药品生产质量管理规范)标准的细胞工厂,确保从患者自身细胞中提取、修正和扩增的细胞产品具备一致的高品质和安全性。这对于构建下一代细胞疗法的供应链至关重要。 第二部分:靶向输送的艺术——纳米医学与药物递送革命 在疾病的治疗层面,仅仅拥有高效的药物分子是不够的,如何确保药物在正确的时间、到达正确的地点,同时避免对健康组织造成附带损害,是现代医学面临的终极挑战。本书将焦点投向了纳米技术在药物递送中的精妙应用。 1. 智能响应性纳米载体(Smart Responsive Nanocarriers): 我们系统地梳理了从脂质体(Liposomes)到聚合物胶束(Polymeric Micelles)的进化史。重点介绍的是具有“智能”的载体,它们能够感应到病灶的微环境特征——例如pH值的酸性、过氧化氢的高浓度、或特定的酶活性——并在此特定信号下选择性地释放有效载荷。这种主动释放机制极大地提高了药物在肿瘤组织内的滞留时间和浓度,显著降低了全身毒性。 2. 靶向配体的设计与优化: 仅仅依靠渗透性来累积药物是不够的,精准的“寻址”系统是关键。本书详细介绍了如何利用适体(Aptamers)、单链抗体片段(scFv)或特定的肽段作为“导航系统”,锚定在疾病细胞表面高表达的特异性受体上。我们对比了主动靶向与被动靶向(如EPR效应)的优劣,并探讨了“双靶向”策略如何进一步提高治疗指数。 3. 突破血脑屏障(BBB):进入“禁区”的策略: 中枢神经系统(CNS)药物的开发历来是生物医学的难点,主要障碍即是功能强大的血脑屏障。本书专门辟出章节,分析了当前最有前景的几种穿透BBB的策略,包括利用转运蛋白介导的内吞作用、破坏紧密连接的局部给药技术,以及载体本身的表面修饰,以模仿内源性分子,欺骗屏障的防御系统。 第三部分:从数据到洞察——计算生物学与个性化治疗 生命科学的爆发式发展产生了海量数据,如何从中提取可操作的临床洞察,是决定未来医疗模式的关键。 1. 组学数据整合与表型预测: 本书探讨了多组学数据(基因组学、转录组学、蛋白质组学、代谢组学)的深度融合,并介绍了计算模型如何利用这些信息来识别疾病的生物标志物和潜在的药物靶点。我们重点阐述了因果推断模型(Causal Inference Models)在从关联性数据中提取有效治疗干预措施中的作用,这使得“假设驱动”的研究正向“数据驱动”的发现转变。 2. 临床试验的虚拟化与优化: 我们审视了“数字孪生”和“器官芯片”(Organ-on-a-Chip)技术在加速药物开发中的应用。这些高保真度的体外模型能够模拟复杂的人体生理环境,允许研究人员在安全、可控的环境中筛选候选药物,并预测其在人体内的药代动力学行为,从而极大地提高I期和II期临床试验的成功率,并减少对动物模型的依赖。 总结: 《探索生命前沿》旨在为读者提供一个全面且深入的视角,理解当前生命科学研究是如何从基础分子机制的解析,逐步迈向可工程化、可精准控制的治疗策略。本书展示了科学界如何以空前的速度和精度,重构我们对生命体、疾病以及治疗手段的理解,预示着一个高度个性化、基于生物工程的健康新时代的来临。

著者信息

作者簡介

Junji Akagi


  Immuno-oncologist
  Specialist and supervising physician of Japan Surgical Society
  Specialist and supervising physician of Japan Society of Gastroenterological Surgery
  Accredited physician for cancer treatment in Japan
  Accredited physician of the Society for Integrative Medicine Japan
  Member of council of the Society for Integrative Medicine Japan and Director of the Kumamoto affiliate
  Director general of International Society for Hydrogen Medicine and Biology

  Dr. Akagi was born in Sasebo City, Nagasaki Prefecture in 1954. After graduating from the College of Liberal Arts of Kyushu University, he attended the School of Medicine of the former Miyazaki Medical University. Intended to become an ideal physician, Dr. Akagi spent day and night studying during his stay at the School of Medicine. In order to gain knowledge and experience, he had even studied in the US at the National Cancer Institute of the National Institutes of Health. While abroad, Dr. Akagi realized the very fact that in every three cancer patients who came to seek treatment, one would eventually die. Although he was disappointed by the situation, he has since striven to rescue terminal cancer patients via every possible measure. Along the way, Dr. Akagi has learned many treatment approaches and chosen to specialize in the field of integrative medicine, where he has met the discipline of hydrogen therapy and established hydrogen immunotherapy as an immunology specialist.

譯者簡介

Wan-Jou Tseng


  Wan-Jou Tseng was a radiographer and sonographer at National University Hospital of Singapore and a postgraduate student of medical ultrasound in Cardiff University. Tseng is a Taiwanese freelance translator specializing in medical and scientific translations.

图书目录

Recommendations
I. Can Oxy-hydrogen be Used to Treat COVID-19?  
By Dr. He-Chang Kuo, M.D., Professor of the School of Medicine of Chang Gung University
II. Does Hydrogen Make Cancer Disappear?-My Opinion about Oxy-hydrogen Therapy
By Dr. Ming-Hsien Huang, Vice Superintendent of E-Da Cancer Hospital
III. Persistence Turns what Seemed Unbelievable Yesterday into the Convention of Tomorrow
By Dr. Wen-Chang Lin, Ph.D., Chairman of Epoch Energy Technology Co., and Ota Hydrogen Biotech
 
Foreword

 
Chapter 1  Some Cancer May Disappear, while Some May Not

Rapid- and Slow-Growing Cancers
Cancer Development Is Contributed by Your Lifestyle
95% Cure Rate of Early Cancer
Advanced and Recurrent Cancer Create a Refractory Condition Within Our Bodies
Diet Therapies Are Helpful but Not Enough
 
Chapter 2  Patients Have No Choice
What Are the Three Major Types of Cancer Treatment?
What Is the "Standard of Care"?
The Reason Why the Standard of Care Fails to Cure Terminal Cancer
The Number of Six Hundred Thousand Cancer Refugees Continues to Grow
One Specific Treatment to Save Cancer Refugees
 
Chapter 3  Immune Deficiency Is an Obstacle to the Success of Antineoplastic drugs and Radiotherapy
The Reason Why Current Treatment Options Aren't Working
Even Cancer Experts Have No Idea about the Importance of Immunity
The Cancer-Immunity Cycle Is the Key to Cancer Prevention
To Build a Robust Body with Your Immunity Is of the Utmost Importance
      
Chapter 4  Curing End-Stage Cancer Patients With Hydrogen
How Can Hydrogen Help to Enhance Immunity?
What Exactly Is Hydrogen?
Lift the Immunosuppression to Achieve Successful Treatment Outcome
Hydrogen Increases Opdivo? Response Rate by 40%
Hydrogen Inhalation Causes No Pain and Suffering
Don't Be Afraid to Know Your Remaining Lifespan. Hydrogen Is Your Helper for
  Cancer Elimination
Hydrogen Activates Mitochondria to Boost Your Immunity!
What Are Mitochondria?
Mitochondria Are the Energy Factory of the Human Body
Fasting Increases Mitochondrial Activity
Hydrogen Improves Mitochondrial Function
Mitochondria Quality, Good or Bad
 
Chapter 5  Simple Habits to Boost Your Immunity
7 Ingredients to Improve Mitochondrial Health
Maximize Your Mitochondria with Aerobic Exercise
40℃ Warm Water Baths and High-Quality Sleep Revitalize the Body
Create Your Own Stress-Relief Strategies
Promote Bowel Health with Japanese Fermented Foods
When Your Immunity Remains Low After Trying Everything 
 
Chapter 6  Return to Work Despite "Having Only Two Months to Live"
Sheltering Cancer Patients, Witnessing Their Recoveries
Clinical Cases of Hydrogen Therapy
Case 1: Ovarian Cancer (Stage 4) /Ms. K.H  33 years old
Case 2: Lung Cancer (Stage 4) /Ms. H.S  62 years old
Case 3: Breast Cancer (Stage 4) /Ms. K.M  46 years old
Case 4: Colon Cancer (Recurrence) /Ms. T.K  77 years old
Case 5: Ureteral Cancer (Stage 4) /Mr. K.K  69 years old
Case 6: Breast Cancer (Recurrence) /Ms. T.M  53 years old
Case 7: Prostate Cancer (Recurrence) /Mr. S.T  79 years old
Case 8: Pancreatic Cancer (Stage 4) /Ms. M.M  81 years old
 
Chapter 7  Hydrogen Prolongs Healthy Lifespan by 10 Years
Reaching the Average Life Expectancy in Good Health
Hydrogen Application Prevents Dementia
Alzheimer's Disease Can Be Prevented via the Prevention of Intracerebral Oxidation
Hydrogen Is a Promising Hope for Treatment of Parkinson's Disease
Hydrogen Facilitates Stroke Treatment and Prevention
The Significance of Hydrogen in Myocardial Infarction Treatment and Prevention
Hydrogen Soothes Myalgia and Arthralgia
Hydrogen Works Through the Same Pathway as Sirtuin Genes (Longevity Genes)
An Age-Related Decline in Mitochondrial Function Is Observed in Males Since Age 42
Remove Excess Fat and Maintain a Slim Body
Stress Reduction-Reducing the Origin of Diseases
 
Chapter 8  The Era of Customized Treatment Approaches
"Optimal Medicine" Is the Evolved Version of Integrative Medicine
The Immunity Helps to Raise the Natural Self-Healing Ability of Our Bodies
Simplify Surgical Procedures by Hydrogen Immunotherapy
Hydrogen Reduces Damage Caused by Radiotherapy and Antineoplastic Drugs
Achieve Healthy Longevity by Mitochondria
 
Conclusion
 

图书序言

  • ISBN:9789571397191
  • 叢書系列:CARE
  • 規格:平裝 / 192頁 / 13.8 x 21 x 1.1 cm / 普通級 / 單色印刷 / 初版
  • 出版地:台灣

图书试读

Foreword

  “Goodness! The tumor in the lymph nodes was gone! We actually have just started the treatment two weeks ago...” As a specialist in immuno-oncology, I have been treating cancer for over three decades. During these thirty years, various cancer therapies have been developed with the advances in the field of medicine. Although they may be helpful to some patient groups, we are still lacking a single treatment that has been recognized to be effective to most people.
 
  I have been attempting day after day, as a doctor, to mitigate the suffering and to prolong the lives of my patients by all means. In my career, I have never seen any patient experiencing such a speedy recovery in just two weeks. Frankly speaking, when Ms. K.H, 68 years old, came in to our hospital two weeks ago, I even thought to myself, “this lady may not be able to leave this place alive.” That’s exactly how serious her condition was.

  The recurrence of her breast cancer had metastasized to her bones, liver, and cervical lymph nodes, generating a substantial mass on the right side of her jaw. I knew from my previous experience that she was in a critical condition, but I wanted to save her still. This desire prompted me to try on something that was introduced to me not long ago—hydrogen, something that is ubiquitous in nature and present in us all.  

  The swelling of the lymph nodes was gone after the application of hydrogen for two weeks.

  Ms. K.H had experienced a breast cancer recurrence and metastases to cervical lymph nodes, resulting in her swollen jaw. After adding hydrogen to the earlier treatment, the swelling disappeared rapidly within two weeks.
 
  In my usual practice, I use immunotherapy to treat cancer and my treatment protocol basically consists of hyperthermia therapy, low-dose antineoplastic drugs, and Opdivo® (the medicine used in cancer immunotherapy). In Ms. K.H’s case, by the addition of hydrogen, I was deeply surprised to see the remission of her hypertrophic right submandibular gland in just a short period of two weeks.

  Since January 2015, Ms. K.H had continued to take antineoplastic drugs, such as Avastin®+paclitaxel, Avastin®+Abraxane®, and Halaven® for treatment of her recurrent breast cancer, but the value of the tumor marker CA 15-3 had been increasing steadily. Until July 6, 2016, the value rose up to 1630 accompanying her lymph node swelling. This soaring trend is specific to patients with breast cancer. Normally, the value of the tumor marker CA 15-3 should be lower than 31.3. An abnormal level this high may be reflective of the potential presence of multiple metastases to bones and liver. Nevertheless, in two weeks after receiving the combined treatment of immunotherapy and hydrogen, the right submandibular gland hypertrophy had disappeared and Ms. K.H was discharged in good health. On August 3, approximately one month later, the CA 15-3 value had decreased to 1132.

  Before I started treating Ms. K.H, I was introduced by one of my friends to a hydrogen generator, and it was suggested that “hydrogen is useful in cancer treatment.” I was not persuaded initially, but after I realized that hydrogen does not result in potential explosion hazard and is beneficial to the human body in many ways, I couldn’t help thinking, “perhaps this is something worth trying.” Afterwards I witnessed Ms. K.H’s case, which brought me to an idea that “hydrogen may become one of the great promises for cancer treatment in the future.”

  Consequently, I have begun to perform ongoing research and established hydrogen immunotherapy at last. This is the first attempt in the world to treat cancer with hydrogen, and we have successfully cured more than 400 patients to significantly prolong the remaining lifespan of many end-stage or recurrent cancer patients. In addition, I published my article in the British academic journal, Oncology Reports, and received considerable attention globally. In December 2018, I gave a speech about “the advent of the application of immunotherapy for advanced cancer—combined immunotherapy” at the 6th World Integrative Medicine Congress held in Shanghai, China (where 2,500 doctors participated). In May 2019, a group of 40 doctors from China attended the event hosted by the Society for Integrative Medicine Japan at Aichi Medical University. Also, in mid-June of the same year, I departed for Guangzhou, China to attend a relevant event.

  Written in the above-mentioned background, this book documents the details of the unprecedented hydrogen immunotherapy in the world. While the standard of care, including antineoplastic drugs and radiotherapy, has failed to cure cancer and becomes a hopeless option by physicians, I wish to inform the distressed or exhausted patients and families of a potentially promising treatment approach, the mechanism and case reports of which are covered in this book. I think, even if you have been told, “there is nothing we can do for you now,” or asked, “are you willing to consider palliative care?” it would be truly a blessing to learn that there is still hope of survival.

用户评价

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这本书的封面设计真是让人眼前一亮,那种深邃的蓝色调配上简洁的字体,营造出一种既专业又带点神秘的氛围。从书名来看,主题似乎非常前沿,让人不禁好奇作者是如何将这些看似不相关的概念——氢气、免疫疗法与癌症的消失——编织在一起的。我期待它能以一种深入浅出的方式,将复杂的生物学原理阐述得清晰易懂,而不是堆砌一堆拗口的术语。如果作者能用生活化的例子来比喻那些高深的科学机制,那就更好了,毕竟对于我们这些非专业人士来说,理解背后的逻辑比记住一堆名词重要得多。我特别关注它在理论基础上的扎实力度,毕竟在医学领域,任何“奇迹”的背后都需要坚实的科学支撑。希望这本书不仅是提供了一种新的希望,更能给我们带来对生命科学新的认知视角。那种兼具严谨性和可读性的平衡感,是衡量一本优秀科普读物的重要标准,期待它能在这方面交出令人满意的答卷。

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坦白说,现在市面上关于“抗癌秘籍”的书籍多如牛毛,很多都是捕风捉影、缺乏实证支撑的“心灵鸡汤”。因此,这本书如果能做到信息来源的透明化和引用的权威性,将极大地提升其可信度。我非常在意作者在描述具体机制时,是否有充分引用顶尖期刊的研究数据作为佐证。一个严谨的作者,应该会诚实地指出目前研究的局限性和未来可能遇到的挑战,而不是一味地夸大疗效。如果能看到详尽的附录、参考文献列表,并且这些引用是来自国际公认的权威机构,那么即使内容再晦涩,我也愿意花时间去钻研。毕竟,在与重病抗争这件事上,可靠性永远是排在第一位的要素,任何含糊其辞都是对读者不负责任的表现。

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从一个资深“书虫”的角度来看,一本真正的好书,它的价值往往体现在它如何挑战既有的认知框架。我对这本书的期待,不仅仅是学习到新的治疗方法,而是它能否提供一个全新的、甚至是颠覆性的视角来看待人体的自我修复机制。如果作者能够以一种哲学思辨的口吻,探讨人类在对抗疾病过程中,与自然界(比如氢气这种基础元素)的互动关系,那就非常深刻了。我希望它能跳脱出纯粹的医学报告范畴,融入一些对生命本质的思考。这种带有思辨色彩的论述,往往能让人在读完之后,对自己的健康乃至生命有更深层次的体悟,而不是仅仅停留在“知识点”的层面。那种读完后能让人静坐沉思许久的书,才是真正的佳作。

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这本书的定价和目标读者群设定,也间接反映了它想达到的深度。如果它定位在面向普通大众的普及读物,那么语言的亲切度和实用性就成了关键;但如果它的目标读者是医学界的同行或相关研究人员,那么详尽的实验数据和严密的逻辑推导就不可或缺了。我个人更偏爱那种“双层结构”的书籍:一方面,它能提供一个给大众理解的科普框架;另一方面,在附录或特定章节中,又能为专业人士提供足够的数据支撑和方法论探讨。这样的设计,使得这本书能服务于更广泛的读者群体,让专业人士能深入挖掘,而初学者也能有所收获。希望作者在内容分级上做得足够细致,让不同背景的读者都能找到属于自己的那份收获,而不是让新手望而却步,让专家觉得浅尝辄止。

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这本书的装帧质感摸起来相当不错,纸张的厚度适中,油墨印刷的清晰度也达到了出版品的上乘水准,这点对于需要反复翻阅的工具书来说非常加分。不过,光有好的外表是不够的,我更关心的是其内容结构是否合理。一个好的叙事结构能引导读者自然而然地进入作者设定的知识体系。我希望作者能够精心设计章节的递进关系,也许可以从宏观的癌症病理谈起,逐步深入到微观的分子层面,最后再回到应用和展望。这样的层次感能让读者的知识吸收过程更加顺畅,避免了信息轰炸带来的疲惫感。如果章节之间的过渡处理得巧妙,用一些引人深思的小标题来连接,那就更棒了。总而言之,阅读体验不仅关乎内容,也关乎阅读的“旅程”设计,希望这本书能提供一段顺畅而引人入胜的旅程。

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